1 research outputs found
Diagnostic performance of several biomarkers for identification of cases of non-communicable diseases among Central Africans
Background: This study determined the diagnostic performance of new
biomarkers for a composite diagnosis of non-communicable diseases
(NCDs) among Central Africans. Methods: This case-control study was
conducted at LOMO Medical Centre, Kinshasa, DR Congo (DRC) between
January \u2013 December, 2008. The cases comprised 226 participants
with concurrent presence of at least 2 or more of NCDs. Anthropometric
parameters and blood pressure were measured while blood samples were
assayed for biomarkers. The receiver operating characteristics curve
and the logistic regression model were applied. Results: Serum selenium
(Se) had specificity and sensitivity of 72.4% and 91.1%, respectively
with an area under the curve (AUC) of 0.802; Nitric oxide (NO)
(specificity: 72.4%; sensitivity: 93.0%) (AUC = 0.800); Thyroid
stimulating hormone (TSH) levels > 6 Mu/L (specificity: 75%;
sensitivity: 65%) (AUC = 0.0.727); serum calcium levels of 65
110g/L (specificity: 76%; sensitivity: 75%) (AUC = 0.822); and daily
salt intake of 6510 g/day (specificity: 75%; sensitivity: 67%)
(AUC = 0.653) in the diagnosis of all NCDs, which were all highly
significant (<0.0001). Conclusion: Serum Se, NO, calcium, TSH and
daily salt intake had high diagnostic performance as biomarkers for
identification of patients with concurrent NCDs in the study
population